University of Massachusetts

University of Southampton

Jonathan Watts

Robert H Brown, Jr

Helene Tran

Michael Moazami

Anastasia Khvorova

Craig C Mello

Ken Yamada

Bruno Miguel Da Cruz Godinho

Erik J Sontheimer

Annabelle Biscans

Sarah Davis

Vignesh Narayan Hariharan

Krishna Sumanth Ghanta

Chantal Ferguson

Zachary Kennedy

Kathryn Monopoli

Daniel O′Reilly

Qi Tang

Samuel Hildebrand

Socheata Ly

Minwook Shin

Hannah Pendergraff

Pranathi Meda Krishnamurthy

Nicholas McHugh

Jacquelyn Sousa

Jillian Caiazzi

Gitali Devi

Dimas Echeverria Moreno

Hassan Gneid

Hans Michael Haitchi

Yann Thillier

Aamir Mir

Feng Wang

Gregoriy Dokshin

The present disclosure provides antisense compounds, methods, and compositions for silencing C9ORF72 transcripts. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with C9ORF72 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with C9ORF72.

Anti-C9ORF72 oligonucleotides and related methods

The present disclosure provides antisense compounds, methods, and compositions for increasing FXN gene expression. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with FXN in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with FXN.

Oligonucleotides targeting frataxin and related methods

This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

Oligonucleotides for SARS-CoV-2 modulation

The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.

Compositions and methods for improved gene editing

The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with ADAM33 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with ADAM33.

Anti-ADAM33 oligonucleotides and related methods

Growing community of inventors

Worcester, MA, United States of America

Jonathan Watts