Genentech, Inc.

Array Biopharma Inc.

Jonathan W Lane

Keith Lee Spencer

Peter J Stengel

Sagar Raj Shakya

Travis Remarchuk

C Gregory Sowell

Chong Han

David Askin

The invention provides processes for preparing a compound of formula I and salts thereof, wherein Ris defined herein, and compounds and intermediates of said formula.

Process for making hydroxylated cyclopentylpyrimidine compounds

The invention provides processes for preparing a compound of formula I and salts thereof, wherein Ris defined herein, and compounds and intermediates of said formula. 

The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.

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Boulder, CO, United States of America

Jonathan W Lane