Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Institut Pasteur

Assistance Publique-Hopitaux De Paris

Université De Paris

Universite Paris 13 - Paris Nord

Jonathan Vigne

Sylvie Bay

Antonino Nicoletti

Giuseppina Caligiuri

Dominique Le Guludec

Disclosed is CD31for use as a molecular imaging target in the molecular imaging of an inflammatory condition. Administering the radiolabeled peptide P8RI as CD31ligand in different rat models of inflammation indeed showed that CD31is present on activated cells in a quantity allowing a detectable signal, whereas the noise signal corresponding to CD31present on activated circulating cells and on other organs or cells not involved in inflammation was little. Also disclosed is a labeled CD31ligand and the use thereof as a molecular imaging agent in the molecular imaging of an inflammatory condition. The molecular imaging of inflammatory sites particularly allows determining whether a subject suffers from or is at risk of having an inflammatory condition or is at risk of recurrence of an inflammatory condition after an anti-inflammatory treatment.

CD31as a molecular target for imaging of inflammation

Growing community of inventors

Paris, France

Jonathan Vigne