Schering Aktiengesellschaft

Bayer Aktiengesellschaft

Jonathan Turner

Gerhard Sauer

Helmut Wachtel

Thomas Brumby

Josef Heindl

Peter-Andreas Loschmann

Belinda Cole

Gerhard Kuhne

Andreas Huth

Dieter Seidelmann

Eckhard Ottow

Kai Licha

Wolfhard Semmler

Margrit Hillmann

Peter A Loschmann

Thomas Dyrks

Preben Olesen

The invention relates to compounds of formula (I): F,(&mdash;A1)(&mdash;B,)(&mdash;W,) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600-1200 nm; A is a &bgr;-amyloid plaque binding biomolecule; B is a &bgr;-amyloid plaque binding colorant; and W is a &bgr;-amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo an din vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a constrasting agent in fluoresecence and transillumination diagnosis in the NIR range. Diagnostic agents containing said componenets are also disclosed.

Optical diagnostic agents for diagnosis of neurodegenerative diseases by means of near infrared radiation (NIR radiation)

Anellated .beta.-carbolines

The new use of ipsapirone for the treatment of Alzheimer's Disease by improving memory is described.

Ipsapirone for the treatment of alzheimer's disease by improving memory

8.alpha.-acylamino ergolines are useful dopamine agonists.

N-(8.alpha.-ergolinyl)-amides

8 beta-substituted ergolines, process for their production and their use

8.alpha.-acylamino ergolines and use as pharmaceutical agents

2-Substituted ergolines ##STR1## wherein C.sub.2  C.sub.3 and C.sub.9  C.sub.10 represent a single of double bond;

2-substituted ergolines

2-Substituted ergolines ##STR1## wherein C.sub.2  C.sub.3 and C.sub.9  C.sub.10 represent a single or double bond;

Growing community of inventors

Berlin, Germany

Jonathan Turner