Boston Scientific Scimed, Inc.

Schneider (usa) Inc.

Scimed Life Systems, Inc.

Alliant Techsystems Inc.

Biotronik Ag

Howmet Corporation

Crs Holdings, Inc.

Schneider Gmbh

Boston Scientific Corporation

Boston Scientific Limited a Corporation Duly Organized Under the Laws of Ireland

Boston Scientific Limited, an Irish Company

Jonathan Swift Stinson

Claude O Clerc

Paul F Chouinard

Jacob Drew Edick

Diane K Burnside

Daniel J Gregorich

Torsten Scheuermann

Matthew D Cambronne

Dennis A Boismier

Barry J O'Brien

Charles Deng

Jan Weber

Michael N Helmus

Steven E Walak

David W Mayer

Louis Toth

Patrick A Haverkost

Martin R Willard

Michael P Meyer

Michael R Forman

Peter G Edelman

Herbert R Radisch, Jr

Timothy Samuel Girton

Steven R Larsen

Joel N Groff

Jason Todd Lenz

Michael Robert Forman

David M Knapp

Thomas A Trozera

Anthony F Tassoni, Jr

M Kevin Richardson

Charles Horace Craig

Kim E Bowen

Stanley R Nelson

Richard B Frank

James E Heilmann

Craig L Wittman

Jan Webber

Richard A Gleixner

Diana K Burnside

Herbert R Radisch

A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has magnesium and one or more additional alloying elements, including aluminum. The alloy has a microstructure comprising equiaxed Mg-rich solid solution phase grains having an average grain diameter of less than or equal to 5 microns and continuous or discontinuous second-phase precipitates in grain boundaries between the Mg-rich solid solution-phase grains, the second-phase precipitates having an average longest dimension of 0.5 micron or less.

Bioerodible magnesium alloy microstructures for endoprostheses

A bioerodible endoprosthesis includes a bioerodible body including an alloy comprising at least 85 weight percent magnesium and at least one high-melting-temperature element having a melting temperature of greater than 700&#xb0; C. The alloy has a microstructure including equiaxed magnesium-rich phase grains and optionally high-melting-temperature intermetallic phases. The equiaxed magnesium-rich phase grains have an average grain diameter of less than or equal to 10 microns. High-melting-temperature intermetallic phases, if present, can have an average longest dimension of 3 microns or less.

An intravascular catheter is disclosed that includes an elongated shaft defined by a wall including at least one port extending through the wall into a lumen. At least one channel may be defined between layers of polymer making up the catheter shaft. The channel extends along at least a portion of the shaft and is in fluid communication with the port. Outer and inner diameters of the catheter may be substantially constant along the length of the catheter.

Crescent channel dye flow enabled guide catheters

A stent-graft comprising a tubular, radially self-expandable, braided structure comprising elongate bioabsorbable filaments, a bioabsorbable adhesive means, and a permanent graft disposed and adhered with the adhesive means to at least a portion of the structure and forming a stent-graft assembly, the permanent graft and the tubular structure are coextensive along at least a portion of the stent-graft.

Stent-graft with bioabsorbable structural support

A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns and second-phase precipitates in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The beta-phase precipitates have an average longest dimension of 0.5 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Medical stents having valves and their methods of manufacture are disclosed. The valve may be basket-shaped and formed integral to a medical stent to prevent undesirable backflow across the valve. The valve can be formed by converting the braided wires of the stent, by providing elastomeric material onto a mold or fixture to form an elastomeric valve, or by attaching a gasket valve. The valve is normally closed but configured to allow easy opening in response to a predetermined condition.

Medical stent with a valve and related methods of manufacturing

A medical implant includes a metallic base, a tie layer, and at least a first layer overlying an outer surface of the tie layer. The tie layer is bonded to at least a portion of a surface of the metallic base. The tie layer includes magnesium or a magnesium-based alloy. The tie layer can have an outer surface comprising dendritic grains. The tie layer can have a rough outer surface defined by pores, projecting grain structures, and/or projecting particles. A method of producing a tie layer on a medical device includes applying magnesium or a magnesium-based alloy to the medical device and cooling the magnesium or the magnesium-based alloy to produce a rough outer surface.

Medical implant including a magnesium-based tie layer

An endoprosthesis includes an expandable tubular body defined by a plurality of struts. In some embodiments, the expandable tubular body includes a bioerodible metal that has at least a first surface region and a second surface region. The first and second surface regions can have different surface oxide compositions. In some embodiments, the first portion has a thermally altered microstructure and the second portion has a wrought microstructure. The thermally altered microstructure can be a cast microstructure comprising dendritic grains. The first portion forms at least a portion of an outer surface of the expandable tubular body. In some embodiments, the expandable tubular body includes iron or a bioerodible iron alloy and at least one surface of the expandable tubular body includes a substantially uniform coating of iron(III) oxide.

Surface treated bioerodible metal endoprostheses

An endoprosthesis can have a member that includes molybdenum and at least one metal selected from the group consisting of titanium, rhenium, yttrium, palladium, rhodium, ruthenium, tungsten, tantalum, iridium, zirconium, hafnium, niobium, chromium, and combinations thereof. The member can have a microstructure characterized by: (a) a molybdenum-rich base region comprising at least 50 weight percent molybdenum, (b) a surface region comprising at least one metal selected from the group consisting of titanium, rhenium, yttrium, palladium, rhodium, ruthenium, tungsten, tantalum, iridium, zirconium, hafnium, niobium, chromium, and combinations thereof, and (c) an inter-diffusion region in which the concentration of molybdenum decreases in the thickness direction from the molybdenum-rich base region to the surface region of the member.

Molybdenum endoprostheses

A temporary stent endoprosthesis that does not require an interventional procedure for removal. The disintegrating stent is preferably made from a bioabsorbable polymer, such as by braiding polymer monofilaments into a tubular mesh shape, and the polymer has fracture initiation sites within it that promotes the disintegration of the stent into small pieces that are harmlessly transported out of the body by the vessel contents. Fracture initiation sites may be created by controlling the heterogenous structure of amorphous and crystalline regions, by introducing internal or surface fracture initiation sites, or use of multiple strands with small section size.

Disintegrating stent and method of making same

Medical devices, such as stents, and methods of the devices are described.

Medical devices and method for making the same

The invention relates to a stent-graft with a bioabsorbable structure and a permanent graft for luminal support and treatment of arterial fistulas, occlusive disease, and aneurysms. The bioabsorbable structure is formed from braided filaments of materials such as PLA, PLLA, PDLA, and PGA and the graft is formed from materials such as PET, ePTFE, PCU or PU.

Embodiments of the present invention relate to medical devices that provide signals to diagnostic equipment such that functionality of an implantable member can be determined. In particular, various designs and structures are utilized to signal tissue growth on an implantable member such as a stent. The tissue growth can limit flow through the stented lumen. If the growth has a thickness above a certain limit, a signal can be detected by diagnostic equipment such that a proper diagnosis can be made.

Medical device that signals lumen loss

Endoprostheses such as stents are disclosed that are, or that include portions that are, bioerodible.

Bioerodible metallic ENDOPROSTHESES

Medical devices, for example, implantable devices such as endoprostheses, include a composite material having a polymer.

Medical devices and methods of making the same

Growing community of inventors

Plymouth, MN, United States of America

Jonathan Swift Stinson