Massachusetts Institute of Technology

The Broad Institute, Inc.

Harvard College

Jonathan Strecker

Feng Zhang

Omar O Abudayyeh

Jonathan S Gootenberg

Bernd Zetsche

David Benjamin Turitz Cox

Alim Ladha

The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a DNA-targeting Cpf1 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Systems, methods, and compositions for targeted nucleic acid editing

The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.

CRISPR-associated transposase systems and methods of use thereof

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Cambridge, MA, United States of America

Jonathan Strecker