Emd Millipore Corporation

Jonathan Steen

Mikhail Kozlov

Herbert Lutz

Bala Raghunath

Elizabeth M Goodrich

Joseph Parrella

George A Gagne, Jr

The present invention provides a filter element () having a radial permeate discharge path (). The filter element generally includes a closed membrane structure () wrapped about a core () in reciprocating clockwise and counterclockwise directions, forming semicircular folds of membrane about the core. The semicircular folds of membrane have opposingly situated apical ends () separated by a gap. The interior of the closed membrane structure () defines a feed channel and the exterior of the closed membrane structure defines at least one permeate channel (). A radial permeate discharge path () extends through the gap between the apical ends of the semicircular folds of membrane. Systems containing, and methods of using, filter elements including radial permeate discharge paths are also provided.

Radial-path filter elements, systems and methods of using same

Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

Processes for filtering liquids using single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate

The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.

Compact spiral-wound filter elements, modules and systems

A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

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Worcester, MA, United States of America

Jonathan Steen