The University of North Carolina at Chapel Hill

Genecentric Therapeutics, Inc.

University of Minnesota

Jonathan Serody

Charles M Perou

Myla Lai-Goldman

David Neil Hayes

Hawazin Faruki

Greg Mayhew

Bruce Robert Blazar

James M Coghill

Benjamin Vincent

Danny Bruce

Heather Stefanski

Methods and compositions are provided for determining a subtype of lung adenocarcinoma (AD) of an individual by detecting the expression level of at least one classifier biomarker selected from a group of gene signatures for lung adenocarcinoma. Also provided herein are methods and compositions for determining the response of an individual with an adenocarcinoma subtype to a therapy such as immunotherapy.

Methods for subtyping of lung adenocarcinoma

Methods and compositions are provided for determining a subtype of lung squamous cell carcinoma (SQ) of an individual by detecting the expression level of at least one classifier biomarker selected from a group of gene signatures for lung squamous cell carcinoma. Also provided herein are methods and compositions for determining the response of an individual with a squamous cell carcinoma subtype to a therapy such as immunotherapy.

Methods for subtyping of lung squamous cell carcinoma

ILC2 cells play a role in the pathogenesis of graft versus host disease (GvHD) and idiopathic pneumonia syndrome (IPS), both conditions associated with allogeneic stem cell transplantation. Infusion of IL-33 activated ILC2 cells into patients with ongoing GvHD or IPS, or prior to onset of GvHD or IPS in susceptible patients, substantially ameliorates the disease and improves survival.

Compositions and methods for preventing and treating graft versus host disease

Growing community of inventors

Duham, NC, United States of America

Jonathan Serody