Health Research, Inc.

Washington University

Jonathan Rickel Wolpaw

Gerwin Schalk

Peter Brunner

Dennis J McFarland

Aiko K Thompson

Xiang Yang Chen

Eric Leuthardt

Daniel W Moran

Jeffrey Ojemann

Eric C Leuthardt

Jeffrey G Ojemann

The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

System and related method to restore and/or improve nervous system functions by modifying specific nervous system pathways

Method and device to restore and/or improve nervous system functions by modifying specific nervous system pathways

A method and system are provided for analyzing electromagnetic brain signals such as EEG and ECoG signals in a subject in real time and which avoids the need for time-intensive retrospective analysis of brain activity in the subject. This can be applied to all complex systems with multiple fluctuating signals to identify and predict significant events.

Method for analyzing function of the brain and other complex systems

An electrocorticography-based brain computer interface (BCI) and related methods are described.

Brain computer interface

The invention contemplates that brain waves, preferably mu rhythm waves of an individual, can control a cursor on a video monitor or other device in the environment. Such communication via mu rhythms is optimized both in real time, and by stored data. The mu rhythms are detected, filtered, and amplified, as an individual sits facing a video, or other display screen. The scalp of the individual has electrodes placed in approximately 64 locations, for monitoring the mu rhythms of the alpha band and/or other EEG rhythms. An ear lobe electrode provides a reference. The electrode signals are fed to a channel differential amplifier which amplifies the difference between the 64 channels and the reference electrode. The signals are digitized and spatially filtered. The resulting signals are submitted to a frequency analysis periodically. The powers n specific frequency bands of specific signals are the independent variables for equations used to control cursor movement. Each variable consists of the amplitude at a specific frequency in a specific signal. Two control channels are provided: one for horizontal movement, and the other for vertical movement. Each control channel is defined by a linear or other equation. The intercept of each equation is based on an average of values of the independent variables that have been stored or recorded from the previous performance of the individual. The cursor moves a plurality of times per second in accordance with the analysis scanning frequency. Movement of the cursor to different portions of the screen can control other processes and devices by invoking programmed commands displayed thereon.

Communication method and system using brain waves for multidimensional

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Delmar, NY, United States of America

Jonathan Rickel Wolpaw