University of California

Other

Jonathan Pegan

Michelle Khine

Joshua Keelyn Kim

Sun-Jun Park

Mark Bachman

Eugene Joseph Lee

Nicole Eckmann

Kimberly Veliz

Francis G Duhay

Michael P Chu

Gareth Forde

Dorsey Ligon

A method of estimating a continuous blood pressure waveform or a continuous blood pressure in a subject including: measuring an arterial blood pressure waveform or an arterial blood pressure with a sensor supported by a supporting structure comprising a polymeric substrate and connected to a processor and a transmitter, wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the processor is configured to quantify one or more signal(s) corresponding to the biological metric and the transmitter is configured to transmit the one or more signals to an external user system, and transforming the arterial blood pressure waveform or the arterial blood pressure to the continuous blood pressure waveform or the continuous blood pressure using a transfer function.

Vital signs monitor

A mobile medical device for monitoring a respiratory condition in a subject, the medical device including: a sensor configured to be adhered to the skin of a patient, the sensor configured to yield a resistance signal that is modulated by movements of a chest of a patient during respiration; a sensor attachment module configured to receive the signal from the sensor and to output data to a mobile electronic device an indication of an adverse respiratory event. Also disclosed is a server for integrating data collected from a plurality of the mobile medical devices and a crowd-sourced respiration advisory system including a plurality of the mobile medical devices and a server for integrating data collected by the mobile medical devices.

Predictive respiratory monitor and system

A wearable sensor apparatus is disclosed that includes a flexible substrate adapted to be coupled with a skin surface of an expectant mother. A conductor is disposed on the flexible substrate. The conductor can include micron-scale invaginations. The conductor can be capable of repeatable variation in resistance when subject to a strain. Also disclosed is a system for monitoring the health of a fetus in utero that includes a wearable sensor apparatus. The wearable sensor apparatus is configured to output a signal responsive to an electrical input. The system includes a computing system with one or more hardware processors. The computing system is programmed to implement a signal processing module configured to access the output signal from the wearable strain gauge and generate an output indicative of health of the baby in utero. The output can be based in part on the received output signal and previously stored correlations between signal data from the wearable strain gauge and observations of the system or of the mother. A user interface module can be provided and can be configured to display an output indicative of health of the baby in utero.

Fetal health monitor

An apparatus comprising a wearable device comprising a supporting structure, a sensor and an electronics module, wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the electronics module is configured to quantify and/or transmit one or more signal(s) corresponding to the biological metric. Some aspects relate to a method of monitoring a biological metric in a subject comprising: adorning a subject with the wearable device; and detecting the biological metric over a period of time in the subject with the wearable device. Other aspects relate to a method of treating a disease in a subject comprising: monitoring a biological metric in the subject over a period of time, and treating the subject with a therapeutic protocol, and monitoring the biological metric in the subject to assess treatment efficacy. Method are provided for estimating a central aortic pressure waveform in a subject comprising: measuring a radial artery pressure waveform in the subject and transforming the radial artery pressure waveform to a central aortic pressure waveform using a transfer function.

A method of making a sensor apparatus including placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate.

Flexible sensor apparatus

A sensor apparatus including a flexible substrate and a wrinkled conductor disposed on the flexible substrate. In some embodiments, the conductor includes micro-scale invaginations. Also disclosed are methods of making a sensor apparatus, including: placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate. Also disclosed are methods of sensing a health condition of a user or patient. The methods include coupling a sensor apparatus to a surface of a user or patient overlying structures to be monitored. The sensor apparatus may include a crumpled conductor capable of detecting strain. Strain is detected by directing current through the sensor apparatus during flexing of the surface and measuring a characteristic of the sensor apparatus based on the strain to generate an output for a user, indicative of the condition of the user or patient.

Growing community of inventors

Irvine, CA, United States of America

Jonathan Pegan