Evotec International Gmbh

Jonathan Paul Shine

Christopher John Brown

Holly Atton

James Lindsay Carr

Daryl Simon Walter

Scott Alexander Sadler

Christopher Francis Palmer

Serge Convers-Reignier

Michael Corr

Marissa Flower

Irena Reboule

Mohamad Sabbah

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R, R, R, R, R, R, R, R, R, R, Aand Ahave the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Modulators of the integrated stress response pathway

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R, R, R, R, R, R, R, R, R, X, X, Aand Ahave the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

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Abingdon, United Kingdom

Jonathan Paul Shine