Elekta, Inc.

Merz Pharma Gmbh & Co Kgaa

Jonathan Mason

Uwe Wortmann

Norbert Kaspers

Johannes Egger

Michael G Kunz

Norihiko Inoue

Simon Schmitt

Martin Emile Lachaine

Franck Villain

Thomas Sowden Reinhold

Michael Kunz

Joseph Stancanello

Inoue Norihiko

Simon Simon

Guido Popp

Roushanak Rahmat

Systems and methods are disclosed for processing of cone beam computed tomography (CBCT) image data, in connection with radiotherapy planning and treatments. Example operations for a radiotherapy workflow include: obtaining a plurality of newly captured CBCT projections that provide imaging of an anatomical area corresponding to an area for radiotherapy treatment; reconstructing a quantitative CBCT image from the plurality of newly captured CBCT projections; identifying anatomical changes of the human patient based on comparing a representation of the anatomical area in the quantitative CBCT image with a representation of the anatomical area in a planning image; and modifying a treatment plan for a radiotherapy workflow based on the anatomical changes, with the treatment plan providing dose calculations for the anatomical area. Further operations for training and use of a regression model to correct CBCT projections and perform additional imaging and radiotherapy data processing operations are disclosed.

Techniques for adaptive radiotherapy based on CBCT projection correction and reconstruction

Systems and methods are provided for performing operations including: accessing a current structural estimate of a region of interest; generating a first simulated X-ray measurement based on the current structural estimate of the region of interest; receiving a first real X-ray measurement; and generating an update to the current structural estimate of the region of interest as a function of the first simulated X-ray measurement and the first real X-ray measurement, the update being generated invariant on the current structural estimate.

Iterative image reconstruction

The present invention generally relates to a mixing nozzle () for mixing at least two liquid compositions such as a first liquid composition and a second liquid composition. The mixing nozzle () is configured to be coupled to a body () of a multi-component application device (), in particular to a body () of a two-component syringe assembly, for injection of a liquid composition, which body () is configured to separately store said at least two solutions. The present invention further relates to a multi-component application device () comprising said mixing nozzle () and to a kit comprising said mixing nozzle () or said application device (). Furthermore, the present invention relates to a method using said application device or said kit, for example for replacing or filling a biological tissue or increasing the volume of a biological tissue.

Mixing nozzle, application device, kit and method using the mixing nozzle or application device

Syringe

Growing community of inventors

St. Albans, United Kingdom

Jonathan Mason