University of Guelph

Nanodesign Inc.

Jonathan Martin Schmidt

Shuguang Zhu

Natalie Lazarowych

Julie Mercure

John Whelan

Stefan Kwiatkowski

Krzysztof Pupek

Peter Redden

Jeffry Lawrence Lowell

Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines and endothelial cells and methods of synthesis are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of cancer through either anti-angiogenesis or other anti-cancer mechanisms. The compounds specified are 6H-dibenzo&lsqb;b,d&rsqb;pyran-6-one derivatives and have been shown to be antiproliferative against human endothelial cells.

Dibenzo&lsqb;c&rsqb;chromen-6-one derivatives as anti-cancer agents

Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyclic derivatives and have been shown to be antiproliferative against human estrogen-dependent cancer cells and to have good binding affinity for the estrogen receptor.

Non-steroidal estrogen receptor ligands

The present invention related to computational methods for designing chemical structures sharing common, useful, functional properties based on specific combinations of steric configuration and binding affinity. More particularly the present invention provides a method for producing computer-simulated receptors which functionally mimic biological receptors. The simulated receptors are designed to exhibit optimized selective affinity for known target molecules. Chemical structures are then generated and evolved to exhibit selective affinity for the simulated receptors.

Computational method for designing chemical structures having common functional characteristics

The present invention relates to computational methods for designing chemical structures sharing common useful, functional properties based on specific combinations of steric configuration and binding affinity. More particularly the present invention provides a method for producing computer-simulated receptors which functionally mimic biological receptors. The simulated receptors are designed to exhibit optimized selective affinity for known target molecules. Chemical structures are then generated and evolved to exhibit selective affinity for the simulated receptors.

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Elora, Canada

Jonathan Martin Schmidt