Avecia Biotechnology, Inc.

Jonathan Mark Hardy

Stephen Edward Dinizo

Stephan Edward Dinizo

A process for the preparation of a compound of formula R&#x2014;Y&#x2014;P(NRR)is provided. The process comprises reacting a compound of formula PXwith a compound of formula HNRRto form a compound of formula X&#x2014;P(NRR); and reacting the compound of formula X&#x2014;P(NRR)with a compound of formula R&#x2014;Y&#x2014;H in the presence of a hydrocarbon solvent to form the compound of formula R&#x2014;Y&#x2014;P(NRR). Rrepresents a phosphorus protecting group; Rand Reach independently represent an alkyl, prefer-ably a Calkyl, group, or Rand Rare joined, together with the N to which they are attached, to form a 5-7 membered ring; Yrepresents O or S, preferably O; and X represents a halogen, preferably Cl. The preferred solvent is toluene.

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Mt Pleasant, TN, United States of America

Jonathan Mark Hardy