Life Technologies Corporation

Quantum-si Incorporated

Butterfly Network, Inc.

Hyperfine Research, Inc.

Bfly Operations, Inc.

Curagen Corporation

Ai Therapeutics, Inc.

454 Life Sciences Corporation

Hyperfine Operations, Inc.

Tesseract Health, Inc.

Raindance Technologies, Inc.

Bio-rad Laboratories, Inc.

Hyperfine, Inc.

Other

Roche Molecular Systems, Inc.

Jonathan Marc Rothberg

Keith Glen Fife

Wolfgang Hinz

Tyler S Ralston

Gregory L Charvat

Nevada J Sanchez

Todd Rearick

James M Bustillo

Kim L Johnson

Lawrence Camest West

Jeremy Lackey

Michael Stephen Poole

Jeremy Christopher Jordan

Jason W Sickler

Benjamin Cipriany

Laura Sacolick

Gerard M Schmid

Ali Kabiri

Paul E Glenn

Christopher Thomas McNulty

Susan A Alie

William Julian Mileski

John Harris Leamon

Brett J Gyarfas

Matthew De Jonge

Michael Weiner

Farshid Ghasemi

Michal Sofka

Hadrien A Dyvorne

Henri Lichenstein

John W Simpson

David Marran

Cedric Hugon

Alan B Katze, Jr

Matthew Scot Rosen

Jonathan C Schultz

Alex Rothberg

Jack L Jewell

David Michael Boisvert

Tomer Gafner

Sean Landrette

Michael W Deem

Darren Roy Link

Jonathan M Schultz

Faisal R Ahmad

Mark James Milgrew

Abraham Neben

Jaime Scott Zahorian

Jan Berka

Jimmy Jia

Kenton L Lohman

David Elgena

Kai Qin Lao

Bin Li

David Ruff

Shiaw-Min Chen

Rachel Kasinskas

Jennifer O'Neil

Jose Camara

Chieh-Yuan Li

Brian Reed

Tian Xu

Paul Francis Cristman

Gregory T Went

Lawrence S Melvin, Jr

John F Davidson

Yi-Ju Chen

John Glenn

Joel S Bader

Paul Beckett

Karl E Thiele

Jianwei Liu

Andrew J Casper

Robert Schneider

Vinod B Makhijani

John Q Lu

Maithreyan Srinivasan

Igor Lovchinsky

Kyle Preston

Lingyun Miao

James Beach

Haidong Huang

Adam Ezra Cohen

Jordan Owens

Rafael O'Halloran

David Light

Carole Lazarus

Krishnan Nandabalan

Jo Schlemper

Prantik Kundu

John R Nobile

Todd Roswech

Peter R Young

Steven M Lefkowitz

Joseph Lutsky

Meijia Yang

Kailiang Chen

James A Ball

Nathan Silberman

Melville Davey

Aspects of the disclosure provide biconjugatable labels, labeled biomolecules, and methods of using and making the same.

Biconjugatable labels and methods of use

The present disclosure provides techniques and apparatus for capturing an image of a person's retina fundus, identifying the person, accessing various electronic records (including health records) or accounts or devices associated with the person, determining the person's predisposition to certain diseases, and/or diagnosing health issues of the person. Some embodiments provide imaging apparatus having one or more imaging devices for capturing one or more images of a person's eye(s). Imaging apparatus described herein may include electronics for analyzing and/or exchanging captured image and/or health data with other devices. In accordance with various embodiments, imaging apparatus described herein may be alternatively or additionally configured for biometric identification and/or health status determination techniques, as described herein.

Biometric identification systems and associated devices

An ultrasound transducer device made by a process that includes the steps of forming depositing a first layer on a substrate, depositing a second layer on the first layer, patterning the second layer at a region corresponding to a location of a transducer cavity, depositing a third layer that refills regions created by patterning the second layer, planarizing the third layer to a top surface of the second layer, removing the second layer, conformally depositing a fourth layer over the first layer and the third layer, defining the transducer cavity in a support layer formed over the fourth layer; and bonding a membrane to the support layer.

Anti-stiction bottom cavity surface for micromachined ultrasonic transducer devices

System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.

Photonic structures and integrated device for detecting and analyzing molecules

Aspects of the technology described herein relate to techniques for calculating, during imaging, a quality of a sequence of images collected during the imaging. Calculating the quality of the sequence of images may include calculating a probability that a medical professional would use a given image for clinical evaluation and a confidence that an automated analysis segmentation performed on the given image is correct. Techniques described herein also include receiving a trigger to perform an automatic measurement on a sequence of images, calculating a quality of the sequence of images, determining whether the quality of the sequence of images exceeds a threshold quality, and performing the automatic measurement on the sequence of images based on determining that the quality of the sequence of images exceeds the threshold quality.

Quality indicators for collection of and automated measurement on ultrasound images

Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.

Compact beam shaping and steering assembly

The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.

Scaffolded nucleic acid polymer particles and methods of making and using

An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced.

Integrated device for temporal binning of received photons

A magnetic resonance imaging (MRI) system, comprising: a magnetics system comprising: a Bmagnet configured to provide a Bfield for the MRI system; gradient coils configured to provide gradient fields for the MRI system; and at least one RF coil configured to detect magnetic resonance (MR) signals; and a controller configured to: control the magnetics system to acquire MR spatial frequency data using non-Cartesian sampling; and generate an MR image from the acquired MR spatial frequency data using a neural network model comprising one or more neural network blocks including a first neural network block, wherein the first neural network block is configured to perform data consistency processing using a non-uniform Fourier transformation.

Deep learning techniques for magnetic resonance image reconstruction

The present invention relates to methods and compositions for treating lymphangioleiomyomatosis in a human subject in need of such treatment. The methods comprise administering to the subject via inhalation an aerosol composition comprising rapamycin or a prodrug or derivative (including analog) thereof.

Rapamycin for the treatment of lymphangioleiomyomatosis

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

Optical system and assay chip for probing, detecting and analyzing molecules

In some aspects, a method of operating a magnetic resonance imaging system comprising a Bmagnet and at least one thermal management component configured to transfer heat away from the Bmagnet during operation is provided. The method comprises providing operating power to the Bmagnet, monitoring a temperature of the Bmagnet to determine a current temperature of the Bmagnet, and operating the at least one thermal management component at less than operational capacity in response to an occurrence of at least one event.

Automatic configuration of a low field magnetic resonance imaging system

Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Methods and apparatus including array of reaction chambers over array of chemFET sensors for measuring analytes

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.

Microfluidic devices and methods of use in the formation and control of nanoreactors

Growing community of inventors

Guilford, CT, United States of America

Jonathan Marc Rothberg