Bial-portela Ca & S.a.

Quantum Genomics

Produits Chimiques Auxiliaires Et De Synthese

Produits Chimiques Auxiliaries Et De Synthese

Jonathan Madec

Jean-Marie Schneider

David Alexander Learmonth

Alexander Beliaev

Fabrice Balavoine

Jorge Bruno Reis Wahnon

William Maton

Nicolas Couvrat

Gerard Guillamot

Yohann Cartigny

Sergio Kreimerman

Gerard Coquerel

Gérard Coquerel

Marie-Noelle Petit

Marie-Noëlle Petit

Gérard Guillamot

The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.

Process for preparing 1,3-dihydroimidazole-2-thione derivatives

The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which Rand R, which may be identical or different, are each a (C-C)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.

Process for preparing cinacalcet and pharmaceutically acceptable salts thereof

Process for preparing 1, 3-Dihydroimidazole-2-Thione Derivatives

The present invention relates to a new method for the preparation of (3S,3S') 4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A.

Method for the preparation of (3S,3S') 4,4&#x2032;-disulfanediylbis (3-aminobutane 1-sulfonic acid)

The present patent application relates to a process for preparing, cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which Rand R, which may be identical or different, are each a (C-C)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.

Method for the preparation of (3S, 3S') 4,4&#x2032;-disulfanediylbis (3-aminobutane 1-sulfonic acid)

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Chatou, France

Jonathan Madec