Histosonics, Inc.

University of Michigan

Jonathan M Cannata

Dejan Teofilovic

Joshua Stopek

Ryan M Miller

Alexander P Duryea

Zeljko Mladenovic

Aleksandra Rakic

Adam D Maxwell

Timothy L Hall

Carol L Shaffer

Erin-Anne Lemieux

Carolyn M Turner

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Histotripsy systems and methods

A system and method, including an ultrasound imaging transducer, an ultrasound therapy transducer, a robotic arm configured to orient the ultrasound imaging transducer and the ultrasound therapy transducer about a patient, a display connected to imaging transducer, and a memory, storing instructions that when executed by a processor receive ultrasound images from the imaging transducer, present ultrasound images, receive an input to alter a shape of a contour line, present the contour line, receive an input of a size of a margin around the treatment area, present the margin, determine end points at locations where X, Y, and Z axes bisect the contour line in an XZ plane and a YZ plane, drive the ultrasound therapy transducer to a location where a focal point of the ultrasound therapy transducer is at the end point, and determining whether a resistance to movement exceeds a threshold.

Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy

Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 &#x3bc;s to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.

Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering

Growing community of inventors

Ann Arbor, MI, United States of America

Jonathan M Cannata