Other

Universiteit Gent

Isis Innovation Limited

Vib Vzw

Jonathan M Austyn

Dermot O'Hare

Bart Lambrecht

Guido Paesen

Stephen Preston

Patricia Nuttal

Dermot M O'HARE

The present invention provides a dendritic cell modulatory protein which modulates, and preferably inhibits, the differentiation and/or maturation of mammalian dendritic cells. The invention also provides proteins comprising conserved motifs found in such proteins as well as pharmaceutical compositions comprising the dendritic cell modulatory protein and homologs and active fragments thereof, antibodies thereto and methods of treatment which utilize such proteins, homologs, fragments and antibodies.

Dendritic cell inhibitory proteins from ticks

The invention provides a long range ordered, layered double hydroxide compound for use in modulating an immune response to an antigen, and an immune modulator composition comprising the layered double hydroxide and an interlayer anion A. The compound is [MM(OH)][A], in which Mis a divalent metal cation or a mixture of two or more divalent metal cations, Mis a trivalent metal cation or a mixture of two or more trivalent meta cations, or a mixture of one or more trivalent metal cation with one or more quadravalent metal cation, x is from 2:1 to 1:4, and A is an interlayer anion having a charge n, wherein optionally some or all of the interlayer anion A may be replaced by one or biologically active agent and/or one or more antigen, and wherein A is selected from conjugate bases of acids having a pKa of &#x2212;4 or higher.

Immune modulation with long range ordered, layered double hydroxides

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Oxford, United Kingdom

Jonathan M Austyn