The State University of New York

Path, Inc.

Samsung Medison Co., Ltd.

Health Research, Inc.

University Health Network

Jonathan Lovell

Shuai Shao

Jumin Geng

Charles Richter King

Wei-Chiao Huang

Kevin Carter

Shwu-Maan Lee

Wentao Song

Ravindra Kumar Pandey

Jung-Ho Kim

Jung-taek Oh

Charles P Jones

Gang Zheng

Dal-Kwon Koh

Jong-Kyu Jung

Blaine Pfeifer

Yumiao Zhang

Chulhong Kim

Dandan Luo

Mansik Jeon

Chul-Hong Kim

Man-Sik Jeon

Elizabeth Huynh

The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules comprising epitopes from microorganisms with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.

Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags

Immunogenic composition are provided comprising PnCo and/or GlpO polypeptides identified as being preferentially expressed during the virulent phase of an infection related to streptococcal bacteria. The compositions can be used for eliciting immune response against streptococcal infections, such as against infections caused by

Pneumococcal vaccine formulations

Provided are serum-stable nanoparticles comprising porphyrin-phospholipid conjugates. Also provided are compositions comprising the nano-particles. The nanoparticles can comprise cargo such as therapeutic agents and/or diagnostic agents (e.g., imaging agents) and be used in drug delivery methods based on NIR stimulated cargo release.

Serum-stable compositions and methods for light-triggered release of materials

A microbubble used as a contrast agent for ultrasound imaging burst due to high intensity of ultrasound, and the burst microbubble effectively acts as a contrast agent for photoacoustic imaging. Based on this point, a new apparatus and method for combined photoacoustic and ultrasound diagnosis are provided.

Apparatus and method for combined photoacoustic and ultrasound diagnosis

The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.

Provided are compositions comprising porphyrin-phospholipid nanovesicles (PoP-NVs) which can be loaded with cargo. Methods for release of cargo from the PoP-NVs triggered by near infrared (NIR) light are also disclosed.

Compositions and method for light triggered release of materials from nanovesicles

Provided are compositions and methods relating to hydrophobic agent loaded-micelle. The micelles comprise surfactant (such as poloxamer) and have hydrophobic agents incorporated therein. The compositions substantially lack surfactant that is not associated with the micelles. The compositions are able to achieve high hydrophobic agent: surfactant molar ratio. The compositions can be used for drug delivery and imaging applications.

Surfactant-stripped micelle compositions with high cargo to surfactant ratio

Growing community of inventors

Niagara Falls, Canada

Jonathan Lovell