Nerviano Medical Sciences S.r.l.

Ignyta, Inc.

Jonathan Lim

Maria Menichincheri

Elena Ardini

Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.

Molecules for administration to ROS1 mutant cancer cells

Methods of treating neuroblastoma associated with a deregulated protein kinase activity are disclosed. The treatment may include administration of substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts therefor, as degined in the specification.

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San Diego, CA, United States of America

Jonathan Lim