University of Nebraska

Vireo Systems, Inc.

Medicines for Malaria Venture (mmv)

Johns Hopkins University

Medicines for Malaria Venture Mmv International Centre Cointrin

Mmv Medicines for Malaria Venture

Medicines for Malaria Venture

Jonathan L Vennerstrom

Donald W Miller

Mark C Faulkner

Hugues Matile

Jacques Chollet

Yuxiang Dong

William Charman

Ravit Boger

Kamaraj Spiraghavan

Maniyan Padmanilayam

William N Charman

Susan A Charman

William N Chapman

Yuanqing Tang

Yuangqing Tang

Lin Zhou

Darren J Creek

Sergio Wittlin

Kamaraj Sriraghavan

Xiaofang Wang

Described are methods of treating or preventing a virus in a subject comprising administering ozonides to the subject.

Ozonides for treating or preventing virus infections

The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.

Creatine oral supplementation using creatine hydrochloride salt

The present invention describes a method for providing creatine to an animal, which includes receiving a creatine ester by the animal. The creatine ester is suitable for being modified by the animal to form creatine.

Creatine ester pronutrient compounds and formulations

The present invention is directed to a third generation form of creatine, specifically a creatine hydrochloride salt, that drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.

A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.

Dispiro 1,2,4-trioxolane antimalarials

Creatine oral supplementation using creatine hydrochloride salt, that may be added to a liquid or other beverage, or may be also used as an additive to solid oral dosages, or as a supplement, and which may be consumed by the athlete, or other party looking for immediate supplementation of strength, and may be added as a supplement within feed to livestock, in the veterinary area.

A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.

Spiro and dispiro 1,2,4-trioxolane antimalarials

Methods are provided for the improved production of a creatine ester by in situ production of an acid catalyst.

Production of creatine esters using in situ acid production

Growing community of inventors

Omaha, NE, United States of America

Jonathan L Vennerstrom