University of Utah Research Foundation

Jonathan L Catrow

Haitao Ji

Min Zhang

Yongqiang Zhang

In one aspect, the invention relates to substituted 5H-[1,2,5]oxadiazolo [3',4&#x2032;:5,6]pyrazino[2,3-b]indole analogs, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and A methods of treating disorders, e.g., various tumors and cancers, associated with a &#x3b2;-catenin/T-cell factor interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3',4&#x2032;:5,6] pyrazino[2,3-B] indole analogs as inhibitors of &#x3b2;-catenin/T-cell factor protein-protein interactions

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Salt Lake City, UT, United States of America

Jonathan L Catrow