Paladin Labs Inc.

Jonathan K Watts

Masad Jose Damha

Glen Deleavey

Masad J Damha

Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2'-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2&#x2032;-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.

Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof

Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2'-sub-stituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2&#x2032;-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.

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Dallas, TX, United States of America

Jonathan K Watts