Igen International, Inc.

Mesoscale Technologies, Llc.

Igen, Inc.

Wellstat Diagnostics, LLC

Other

Pdl Biopharma, Inc.

Eisai Company, Limited

Hyperion Catalysis International, Inc.

Defined Diagnostics, LLC

Meso Scale Technology Llp

Jonathan K Leland

Eli N Glezer

Mark A Billadeau

Richard J Massey

Mark T Martin

Jack E Goodman

Michael Joseph Powell

Jeff D Debad

Bandele J Jeffrey-Coker

Joseph M Leginus

Sriram Jambunathan

Koustubh A Phalnikar

Gary F Blackburn

George B Sigal

Michael Tsionsky

Larry Helms

Glenn D Zoski

John T Grosser

Svetlana Leytner

Fabian Jameison

Ali Ghaed

John H Kenten

Alan B Fischer

Robert Hoch

Charles Quentin Davis

Richard Alan Cook

Haresh P Shah

George E Lowke

Liwen Dong

Pam Liang

Leopoldo Della Ciana

Walter J Dressick

Mohindar S Poonian

David B Talley

Jason Charles Harley

Rober Krikor Matikyan

Janel K Hino

Jeffrey Howard Peterman

Ming Lu

Selen Altunata

Yuzaburo Namba

Sang Cho

Kevin E Dorsey

Sjef Otten

Brian B Thomas

Charles A Wijayawardhana

Allen J Bard

Jeffery D Debad

Thomas J Richards

Selen Stromgren

Elizabeth W Wilkins

Stephanie A Hayes

Lee O Hall

Ralph A Kamin

Ali Ghead

Laurette Nacamulli

Eli N Glazer

Eli Glazer

Jambunathan Sriram

Jeffrey-Coker Bandele

Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

Assay cartridges and methods of using the same

The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

Kits suitable for use in electrochemiluminescence methods and methods of effecting a specific-binding non-wash assay

Provided is a filtration module for separating plasma from blood comprising a feeder channel lid, a feeder channel defined by a feeder channel laminating layer having a thickness of less than 5 mil, a filter element in fluid communication with the feeder channel and having a pore size of less than 2 microns and low surface area, and a filtrate take-off port having a dead volume of less than 10 &#x3bc;L. Also provided are methods for filtering a blood sample comprising supplying the blood sample to a feeder channel of a filtration module and drawing the blood sample over a filter element of the filtration module in a single pass process configuration to provide a retentate and a plasma filtrate.

Filtration module

Provided is a filtration module for separating plasma from blood comprising a feeder channel lid, a feeder channel defined by a feeder channel laminating layer having a thickness of less than 5 mil, a filter element in fluid communication with the feeder channel and having a pore size of less than 2 microns and low surface area, and a filtrate take-off port having a dead volume of less than 10 &#x3bc;I. Also provided is a method for filtering a blood sample comprising supplying the blood sample to a feeder channel of a filtration module and drawing the blood sample over a filter element of the filtration module in a single pass to provide a retentate and a plasma filtrate.

A diagnostic system is provided herein that includes an instrument comprising an electrochemiluminescence (ECL) detector, and a cartridge configured to fit within a portion of the instrument, wherein the cartridge includes at least one reagent including an ECL label and a blood collection holder. Also provided herein is a system that includes a diagnostic instrument, which includes a pump, an ECL detector, an incubator, a magnet, and an output device, and a cartridge configured to fit within a portion of the diagnostic instrument, a sample holder configured to fit within the cartridge, and a closed fluidic loop between the diagnostic instrument and the cartridge when the cartridge is fit within a portion of the diagnostic instrument, wherein the cartridge is configured to accept a sample from the sample holder and place the sample in fluidic communication with the diagnostic instrument via the closed fluidic loop.

Clinical diagnostic systems

Graphitic nanotubes, which include tubular fullerenes (commonly called 'buckytubes') and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

Graphitic nanotubes in luminescence assays

In embodiments disclosed herein, a diagnostic system is provided having a cartridge comprising at least one needle; at least one reservoir; at least one fluidic seal; and at least one fluidic channel of a fluidic pathway, wherein the cartridge is configured to store at least one reagent and at least one waste material on the cartridge. The diagnostic system is provided also having a diagnostic instrument comprising the fluidic pathway; an electrochemiluminescence (ECL) detection system; and a pump, wherein the fluidic pathway begins and ends in the cartridge and has a substantially single direction of flow in a pathway fluidically connecting the diagnostic instrument and the cartridge.

Clinical diagnostic system including instrument and cartridge

Provided is a clinical diagnostic system that comprises a diagnostic instrument and a disposable cartridge. The diagnostic system can be used to measure assays in point of care clinical settings.

Diagnostic systems and instruments

A clinical diagnostic system is disclosed, including a clinical diagnostic instrument with a disposable cartridge. The disposable cartridge is capable of performing diagnostic and analytical functions including filtering samples such as plasma from whole blood and running assays and collecting measurements of analytes or biomarkers.

Diagnostic systems and cartridges

Assay buffer, compositions containing the same, and methods of using the same

Growing community of inventors

Silver Spring, MD, United States of America

Jonathan K Leland