Cyclacel Limited

Jonathan James Hollick

Stuart Donald Jones

Claire June Flynn

Michael George Thomas

Start Donald Jones

Micheal George Thomas

The present invention relates to pyrimidine derivatives capable of inhibiting one or more protein kinases. Further aspects relate to pharmaceutical compositions comprising the pyrimidine derivatives and the use thereof in the treatment of proliferative disorders.

Pyrimidine derivatives as protein kinase inhibitors

The present invention relates to a compound of formula (VII)I, or pharmaceutically acceptable salt or ester thereof, wherein: X is NR; Y is O or N&#x2014;(CH)R; n is 1, 2 or 3; m is 1 or 2; Rand Rare each independently H, alkyl or cycloalkyl; Rand Rare each independently H or alkyl; or Rand Rtogether form a spiro cycloalkyl group; Ris H, alkyl, aryl or a cycloalkyl group; Ris ORor halogen; and Rand Rare each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like. 

The present invention relates to a compound of formula (VII)I, or a pharmaceutically acceptable salt or ester thereof, wherein: X is NR; Y is O or N&#x2014;(CH)R; n is 1, 2 or 3; m is 1 or 2; Rand Rare each independently H, alkyl or cycloalkyl; Rand Reach independently H alkyl; or Rand Rtogether form a spiro cycloalkyl group; Ris H, alkyl, aryl or a cycloalkyl group; Ris ORor halogen; and Rand Rare each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like. 

Growing community of inventors

Perth, United Kingdom

Jonathan James Hollick