The Scripps Research Institute

Abide Therapeutics, Inc.

Jonathan J Hulce

Benjamin F Cravatt

Micah J Niphakis

Armand Cognetta

Kenneth M Lum

Bruno Correia

Todd Kevin Jones

Cheryl A Grice

Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.

Lipid probes and uses thereof

Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.

N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets

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San Diego, CA, United States of America

Jonathan J Hulce