The University of Chicago

Ucl Business Plc

Medstar Health

Barts Health Nhs Trust

Jonathan Grinstein

Hector Manuel Garcia Garcia

Ryo Torii

Nir Uriel

Christos Bourantas

A model of flow through a left ventricular assist device (LVAD) can be used for preoperative planning of implantation of the LVAD into a patient and/or optimization of the LVAD after implantation into the patient are described. At least one imaging data set related to a patient and at least one physiological data set related to the patient can be received. An ideal parameter related to the LVAD can be determined based on the at least one imaging data set related to the patient, the at least one physiological data set related to the patient using a model of circulation in a large spatial region of the patient's body and a three-dimensional anatomical model of at least one component of the region of the patient's body and at least one component of the LVAD. Flow patterns within the three-dimensional anatomical model are calculated using computational fluid dynamics.

Modeling of flow through a left ventricular assist device (LVAD)

A controller is provided to determine a ventricular filling phase slope as an indicator of high pulmonary capillary wedge pressure and/or cardiac index. Flow rate values describing a blood flow rate through a ventricular assist device are received. A ventricular filling phase segment is identified from a portion of the received flow rate values. A slope of the received flow rate values during the identified ventricular filling phase segment is determined. The determined slope is compared to a predetermined threshold value. When the determined slope exceeds the predetermined threshold value based on the comparison, a warning is triggered regarding an elevated pulmonary capillary wedge pressure or a low cardiac index value.

Ventricular filling phase slope as an indicator of high pulmonary capillary wedge pressure and/or cardiac index

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Chicago, IL, United States of America

Jonathan Grinstein