Be Pharbel Manufacturing

Ucb Farchim Sa

Jonathan Goole

Michel Deleers

Domenico Fanara

Federica Ronchi

Geoffrey De Bilde

Pierre Sacre

Karim Amighi

Olivier Laloux

Georges Guillaume

Vincent Stephenne

A controlled-release multilayer microparticle containing a pharmaceutically active compound, which is intended for oral administration or direct administration in the stomach, which may be done using a liquid pharmaceutical composition containing the microparticle. The microparticle may include: a core that includes the pharmaceutically active compound, which may be pramipexole; a controlled-release intermediate coating layer; and an outmost external protection coating layer surrounding the controlled-release intermediate coating layer. The external protection coating layer may include a mixture of: a hydrophilic gastro-soluble component which is insoluble in aqueous media at a pH of between 6.5 and 7.5; and a hydrophobic and/or insoluble component. Also disclosed are a liquid pharmaceutical composition containing the microparticles, a kit for the preparation of the liquid pharmaceutical composition, a pharmaceutical solid composition reconstitutable as the liquid composition, a process of preparing the liquid composition, and a method for treating disease with the liquid composition.

Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form

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Woluwe-Saint-Lambert, Belgium

Jonathan Goole