Glucovista Inc.

Gerlitz, Jonathan

Jonathan Gerlitz

Embodiments of the present system and methods measure a concentration of a substance, such as glucose, in a body. The present embodiments measure a first amount of infrared (IR) radiation absorbed or emitted from the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the body in a second wavelength band. The present embodiments also measure a temperature at a surface of the body and an ambient temperature. A normalized ratio parameter is calculated from the four measurements, and the concentration of the substance in the body is calculated by correlating the normalized ratio parameter with the body surface temperature and the ambient temperature using an empirically derived lookup table. Also disclosed are methods for creating the empirically derived lookup table.

Apparatus and methods for non-invasive measurement of a substance within a body

A method determines the concentration of a substance in a subject's blood. The method includes measuring an interaction of at least one light beam with a portion of the subject's body. The method further includes calculating a value of an optically-measured parameter indicative of the interaction of the at least one light beam with the substance in the portion of the subject's body. The method further includes measuring values of one or more temperature-indicative parameters corresponding to a temperature of the portion of the subject's body. The method further includes accessing an empirical correlation of the optically-measured parameter and the one or more temperature-indicative parameters to concentrations of the substance in blood. The method further includes obtaining a concentration of the substance in the subject's blood using the empirical correlation. The concentration corresponds to the value of the optically-measured parameter and the values of the one or more temperature-indicative parameters.

Apparatus and method for non-invasive measurement of the concentration of a substance in subjects blood

An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye.

Non-invasive glucose meter

A method determines the concentration of a substance in a subject's blood. The method includes noninvasively irradiating an eye with a measurement light beam having a first wavelength and a first power and with a reference light beam having a second wavelength and a second power. The second wavelength is different from the first wavelength. The method further includes measuring at least one of a body temperature of the subject and an ambient temperature of the subject. The method further includes detecting a power of the measurement retro-reflected light beam and detecting a power of the reference retro-reflected light beam. The method further includes calculating a measurement ratio of the detected power of the measurement retro-reflected light beam and the first power and calculating a reference ratio of the detected power of the reference retro-reflected light beam and the second power. The method further includes calculating a parameter dependent on the measurement ratio and the reference ratio and determining a concentration of the substance in the subject's blood in response to the calculated parameter and to the at least one of the body temperature and the ambient temperature.

Apparatus and method using light retro-reflected from a retina to non-invasively measure the blood concentration of a substance

An apparatus for measuring a concentration of a substance in an eye () includes a measurement light source () producing a measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient. The apparatus further includes a reference light source () producing a reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. At least a portion of the measurement light beam retro-reflects from the retina () and at least a portion of the reference light beam retro-reflects from the retina (). The apparatus further includes a detector () responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal.

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Herzliya, Israel

Jonathan Gerlitz