Ginkgo Bioworks, Inc.

Flagship Pioneering Innovations V, Inc.

Novogy, Inc.

Jonathan Friedlander

Arthur J Shaw, Iv

Elena E Brevnova

Vasiliki Tsakraklides

Annapurna Kamineni

Johannes Pieter Van Dijken

Barry Andrew Martin

Ignacio Martinez

Maier Steve Avendano Amado

Zachary Garo Armen

Maureen Hamilton

Christine Cezar

Disclosed are transformed cells comprising one or more genetic modifications that affect the lipid content of the cell, e.g., by increasing the concentration of oleic acid in the cell relative to an unmodified cell of the same type. Also disclosed are methods for modifying the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the same cell.

Oleic acid production in yeast

Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.

Compositions and related methods for agriculture

Disclosed are transformed cells comprising one or more genetic modifications that increase the lipid content of the cell, e.g., relative to an unmodified cell of the same type. Also disclosed are methods for increasing the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the cell.

Enhanced production of core lipids in oleaginous yeasts

Growing community of inventors

Cambridge, MA, United States of America

Jonathan Friedlander