3m Innovative Properties Company

Massachusetts Institute of Technology

Solventum Intellectual Properties Company

Jonathan F Hester

Robin Edgar Wright

Derek J Dehn

Brian Edward Spiewak

Anne M Mayes

Jinsheng Zhou

Daniel P Meehan

Jerald K Rasmussen

Clinton P Waller, Jr

James Stephen Mrozinski

Robert Steven Kody

Andrew W Vail

Pallab Banerjee

Ariya Akthakul

Gregory M Jellum

Moses Mekala David

James M Nelson

Michael R Berrigan

Kannan Seshadri

Michael K Domroese

David F Slama

Douglas Eugene Weiss

David R Holm

Brinda Balasubramaniam Lakshmi

Michael John Annen

Seth M Kirk

Brent R Hansen

John J Emmel

Philip D Radovanovic

Francis E Porbeni

Karl-Dieter Weilandt

Harold Todd Freemyer

Jerald W Hall, Jr

Karl B Richter

John J Schmidt

David J Colburn

Timothy L Quinn

Stefan R Reimann

David G Walton

Ali E Ozcam

Randall P Swenson

Alexei M Voloshin

Eric J Olson

Angelines A Castro Forero

Peter B Zenk

Clinton P Waller

Daniel R Meehan

Described herein is method for testing an ion exchange chromatography device. The method includes monitoring both a binding and a non-binding species and determining their breakthrough point to determine a net breakthrough value. The method can be used to determine the integrity of the chromatography device, ensure that the chromatography device possesses the expected adsorbent capacity, and/or determine viral clearance of the chromatography device.

Method for testing a chromatography device used for ion exchange

Described herein is a filtration media comprising: (i) a first filtration medium comprising an anion exchange nonwoven substrate, wherein the anion exchange nonwoven substrate comprises a plurality of quaternary ammonium groups; and (ii) a second filtration medium comprising a functionalized microporous membrane wherein the functionalized microporous membrane comprises a plurality of guanidyl groups; wherein the first filtration medium is positioned upstream of the second filtration medium.

Filtration medium sequence for biomaterial purification

A method of purifying a biological composition includes: disposing loose cationic ligand-functionalized staple fibers and a biological composition within a mixing volume of a vessel; agitating the biological composition and the loose cationic ligand-functionalized staple fibers while they are in intimate contact with each other within the mixing volume to provide modified fibers and a purified biological composition; and separating at least a portion of the purified biological composition from the modified fibers and any loose cationic ligand-functionalized staple fibers with which it is in contact. The loose cationic ligand-functionalized staple fibers have a modified surface layer comprising a grafted acrylic polymer comprising 10 to 100 percent by weight of a cationically-ionizable monomer unit. An article for purifying a biological composition includes: a vessel having a mixing volume disposed therein; and the loose cationic ligand-functionalized staple fibers disposed within the mixing volume.

Method of purifying a biological composition and article therefor

The present disclosure provides methods for forming asymmetric membranes. More specifically, methods are provided for applying a polymerizable species to a porous substrate for forming a coated porous substrate. The coated porous substrate is exposed to an ultraviolet radiation source having a peak emission wavelength less than 340 nm to polymerize the polymerizable species forming a polymerized material retained within the porous substrate so that the concentration of polymerized material is greater at the first major surface than at the second major surface.

Method of forming an asymmetric membrane

Microporous material having a spherulitic matrix made from ethylene chlorotrifluoroethylene copolymer has a plurality of pores having an average pore size greater than about 0.01 micrometer. The material is made by thermally induced phase separation (TIPS) process that includes melt mixing ethylene chlorotrifluoroethylene copolymer, diluent and nucleating agent to provide a melt mixed composition; shaping the melt mixed composition; cooling the shaped melt mixed composition to induce phase separation of the ethylene chlorotrifluoroethylene copolymer to provide a phase separated material; and stretching the phase separated material to provide the microporous material. The microporous material may be incorporated into articles and the articles may include one, two or more layers of microporous material.

Microporous material from ethylene-chlorotrifluoroethylene copolymer and method for making same

A functionalized nonwoven substrate and methods for preparing the same are described. The functionalized substrates are useful in selectively filtering and removing biological materials, such as biocontaminates, from biological samples.

Nonwoven article grafted with copolymer

The present disclosure provides rewettable asymmetric membranes and methods of forming rewettable asymmetric membranes. More specifically, methods are provided for forming rewettable asymmetric membranes having a copolymer and a polymerized material retained within the porous substrate.

Method of forming a rewettable asymmetric membrane

The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.

Graft copolymers, methods for grafting hydrophilic chains onto hydrophobic polymers, and articles thereof

The invention is a display article having a flexible substrate which includes a writing surface capable of being used as a dry erase surface. A peripheral edge extends around the writing surface. A flexible framing strip is affixed to the writing surface at a position proximate to the peripheral edge. One embodiment of the display article can be made by forming a substrate having a writing surface. The substrate defines a periphery edge, a back surface, and a plurality of mushroom shaped hooks extending from the back surface substantially over the entire back surface. The writing surface is capable of being used as a dry erase surface. At least a portion of the periphery of the writing substrate is folded over to form a framing strip having a plurality of exposed mushroom shaped hooks. The framing strip is secured to the writing surface.

Dry erase article

The invention features integrated membrane assemblies for selectively transferring a constituent to or from a fluid. The assemblies include two or more flat sheet membrane elements and at least one common manifold connected to the interior regions of the membrane elements.

Membrane modules and integrated membrane cassettes

Described is an apparatus for the removal of organic substances and/or nitrogen sources from an aqueous medium by exposing the aqueous medium to the action of microorganisms supported on a gas permeable, water impermeable layer, or on and/or in a three dimensional microbial support layer, that is proximate a gas delivery layer through which gas, preferably, oxygen-containing gas, is supplied to the gas permeable layer such that it diffuses through the gas permeable layer and is supplied to the microorganisms.

Layered sheet construction for wastewater treatment

A layered sheet construction contains at least one gas permeable, liquid water impermeable layer, and a gas delivery layer formed of a corrugated sheet proximate the gas permeable, water impermeable layer. The corrugated sheet has corrugations that form flow channels through which gas can be conveyed to the gas permeable layer. One embodiment of the layered sheet construction includes a gas permeable, liquid water impermeable layer having a surface energy that is below 20 dynes per centimeter.

Membrane module elements

The present invention includes a membrane construction for selectively transferring a constituent to or from a fluid. The membrane construction includes a multi-layer fluid impermeable support sheet having a plurality of supports on at least one side of the support sheet that form a plurality of flow channels. At least one layer of the multi-layer support sheet is a bonding layer. A fluid permeable layer extends over the flow channels and is bonded to the plurality of the supports by the bonding layer.

Fluid separation membrane module

Growing community of inventors

Hudson, WI, United States of America

Jonathan F Hester