Altea Therapeutics Corporation

Nitto-denko Corporation

Spectrx, Inc.

Altea Technologies, Inc.

Other

Abbott Laboratories Corporation

Respironics, Inc.

Ntt Denko Corporation

Passport Technologies, Inc.

Jonathan Eppstein

Stuart McRae

Michael R Hatch

Alan Smith

Zoran Novakovic

Bernadette Messier

Krishna Kumar

David Farquhar

Joseph Papp

Stuart Mcrae

Jeremiah P O'Leary

Mark A Samuels

Mark James Fisher

Mark L Faupel

Uros Kascak

Stephen Wilson Braun

Loren J Lantz

Wendy E Bowerman

Regina Spiehl

Erin Koch Henkel

Keith D Ignotz

Frank Tagliaferri

David Enscore

Gaurav Tolia

Yogi Patel

Shulun Chang

Timothy P Henning

Mark R Pope

Peter M Bojan

Danny F Lincoln

Neil W Loomis

Difei Yang

Gregory J Newman

Harry K Delcher

Fan Xu

Brian Krantz

Stuart McRAE

Peter N Bojan

A transdermal permeant delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

Transdermal porator and patch system and method for using same

A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.

Microporation of tissue for delivery of bioactive agents

Providing a method for monitoring an analyte extracted from a patient and delivering a permeant composition to the patient. The method includes the steps of a) contacting a poration device to a tissue membrane of the patient, the poration device including at least one porator array; b) actuating poration of the tissue membrane using the at least one porator array in the poration device; c) extracting the analyte from the porated tissue membrane by way of the at least one porator array; d) analyzing the analyte to determine a concentration of the analyte within the tissue membrane; and e) delivering a permeant composition to the tissue membrane by way of the at least one porator array.

Transdermal integrated actuator device, methods of making and using same

A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.

Method for transdermal delivery of permeant substances

The invention provides for a device for delivering a drug comprising: The invention also provides for methods of making and methods of using the same.

A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: The invention also provides for methods of making and methods of using the same.

The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: The invention also provides for methods of making and methods of using the same.

Transdermal drug delivery patch system, method of making same and method of using same

A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.

System and method for continuous analyte monitoring

A transdermal drug delivery device for forming a micropore in a tissue membrane of an animal comprising a substrate and a porator that is located on or within the substrate. The porator is constructed of a material that is destroyed upon forming the micropore. The transdermal drug delivery device also comprises at least one reservoir and a controller for controlling the formation of said micropore by the porator and destroying the porator after the formation of the micropore.

Transdermal drug delivery device, method of making same and method of using same

A fluid collection and sensor device for placement over at least one artificial opening made in a biological membrane for measuring a characteristic of a biological fluid collected from the tissue through the at least one artificial opening. The device comprises a sensor positioned in a flow path of the biological fluid for contacting a quantity of the biological fluid and generating an indication of a characteristic of the biological fluid. According to one aspect of the invention, a waste fluid storage element, such as a reservoir, is positioned in the device to collect the biological fluid after it has made contact with the sensor. According to another aspect of the invention, various surfaces of the fluid flow path of the fluid collection and sensor device are treated with an agent to limit or minimize clotting, aggregation or sepsis of the biological fluid, blockage or clogging of the flow path or degradation of the sensor. According to still another aspect of the invention, various configurations of a fluid sensor and collection device are provided that are designed to ensure that measurements are made on independent fluid samples.

System and method for fluid management in a continuous fluid collection and sensor device

An improved light beam generation and focusing device () has a light source () constructed and arranged to emit at least one beam of light (), and a lens assembly () constructed and arranged to focus the at least one beam of light on a surface plane. The device is constructed and arranged to sequentially direct the at least one beam of light to at least two spaced locations (') on the surface plane. The lens assembly comprises a collimating lens (), and a spaced focusing lens ().

Light beam generation, and focusing and redirecting device

Growing community of inventors

Atlanta, GA, United States of America

Jonathan Eppstein