Oriel Therapeutics, Inc.

Bayer Healthcare LLC

Tecpharma Licensing Ag

Novartis Ag

Jonathan David Tuckwell

Scott Alexander Lewis

Andrew Murray Gow

Thomas W Ruckdeschel

David Stuart Harris

Rachel Striebig

Matthew Allen

Charles A Buckner, Iii

James Grant Skakoon

David A Schuelke

Gerald A Thoe

Edward William Vernon-Harcourt

Ben Arlett

Robert Owen Kivlin

Peter Schwan

Michael John Dunkley

Lee Wood

Robert Dyer

John Paul Palmer-Felgate

Matthew Burgess Avery

Kevin George Skinner

Chris Kadamus

Scott Clifford Harris

Ulrich Moser

Markus Tschirren

Jürg Hirschel

Richard Mann

Martin Wymann

Sameer Shirgaonkar

Steve Paboojian

Mark J Glusker

Annette Drunk

Kevin Mori

Céline Kaenel

Patrick J Ryan

Greg Beard

Andrew D Pidgeon

Charles A Buckner

Ed Vernon-Harcourt

A Charles Buckner Iii

LEWIS;Scott Alexander

Methods of fabricating and operating dry powder inhalers that include dose disks and airway channel disks with sealant layers, the airway channel disks forming radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Dry powder dose container assemblies and related inhalers

A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Dry powder inhalers with dual piercing members and methods of operating same

Methods of operating and fabricating inhalers with airway disks having discrete airway channels

A reconstitution device having an opening surrounded by a neck, and a cap including a first end, a second end, and an inner bore having a central aperture. A stopper is positioned in the opening of the neck and includes a portion capable of being perforated. A plunger is located at the second end of the cap, is configured to slide along the inner bore of the cap, and includes a shaft extending downwardly in a direction towards the stopper and having a pointed end for piercing the stopper. A locking mechanism is located in the cap and includes an aperture. The locking mechanism is configured such that when the plunger is pushed downwardly the shaft is allowed to pass through the aperture, but when the plunger is pulled upwardly the second aperture changes shape such that the shaft cannot freely pass through the aperture.

Reconstitution device

Dry powder inhalers with dual piercing members

A device for administering a product (e.g. a medicinal or therapeutic substance), the device including a receptacle for the product or constituents of the product and a casing, wherein the receptacle and casing are engaged, and an outer sleeve, wherein the casing can be moved relative to the receptacle into the outer sleeve.

Mixing device for a two-chamber ampoule

Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Inhalers with airway disks having discrete airway channels and related disks and methods

Dry powder inhalers with rotatable piercing mechanisms facilitate the use of dose container assemblies having dose containers arranged in concentric rows. A piercing mechanism is operably associated with the dose container assembly and is configured to pierce sealants that seal a dose container. The piercing mechanism is rotatable such that it can serially alternate between the two rows of dose containers. The piercing mechanism includes a rotatable drum, an elongate piercing member, and a biasing member operably associated with the piercing member. The rotatable drum has an open end, an opposite closed end, and a cylindrical wall that extends from the closed end and terminates at the open end. The closed end includes an aperture formed therein in a location adjacent to the wall. The elongate piercing member is extended and retracted through the aperture to pierce the sealants of a dose container.

Dry powder inhalers with rotating piercing mechanisms and related devices and methods

A reconstitution device for storing a first component of a pharmaceutical preparation includes a receptacle, a cap having a first end secured to the receptacle, a second end, and an inner bore having a central aperture. The device further includes a stopper located between the receptacle and the cap, the stopper including a portion capable of being perforated. The device also includes a plunger secured to the second end of the cap, a locking mechanism located in the cap, and an actuating mechanism. The actuating mechanism may prevent the device from inadvertent activation.

Dry powder inhalers with dual piercing members and related devices and methods

Growing community of inventors

Cambridge, United Kingdom

Jonathan David Tuckwell