Leland Stanford Junior University

Alvine Pharmaceuticals, Inc.

Celiac Sprue Research Foundation

Jonathan David Gass

Chaitan Khosla

Michael Thomas Bethune

Lu Shan

Gary Gray

Gail G Pyle

Matthew John Siegel

Indu Isaacs

Gregg Strohmeier

Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.

Enzyme treatment of foodstuffs for celiac sprue

A combination enzyme product consisting of a glutamine specific endoprotease and a prolyl endopeptidase is provided. Both enzymes are active and stable in the stomach and can therefore be administered as lyophilized powders or simple capsules/tablets. A ratio of the two enzymes is used to maximize their synergy.

Combination enzyme therapy for digestion of dietary gluten

Methods and compositions are provided for stabilizing polypeptides for oral administration, particularly where enteric delivery is desirable. By administering the polypeptides with a bile sequestering agent, the stability of the polypeptide can be increased. Pharmaceutical formulations for this purpose are provided.

Compositions and methods for enhanced gastrointestinal stability of oligopeptides and polypeptides

Pharmaceutical formulations of glutenase enzymes are provided. The enzymes find particular use in the treatment of a Celiac or dermatitis herpetiformis patient.

Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis

Enzyme treatment of foodstuffs for Celiac Sprue

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Mountain View, CA, United States of America

Jonathan David Gass