Battelle Memorial Institute

Jonathan D Suter

Raymond Shane Addleman

Curtis J Larimer

George T Bonheyo

Allan T Evans

Rebecca L Erikson

Michelle R Brann

Jacob M Fricke

An apparatus and method of measuring biofilm and biological activity on a surface is disclosed. The apparatus includes a biofilm, which includes one or more microorganisms, grown on a substrate. A viewing window is placed on a surface of the biofilm and a gas bubble is introduced between the viewing window and the surface of the biofilm. The space between the substrate and the viewing window may be enclosed in a casing that has an inlet and an outlet, forming a flow cell. A microscope system, such as a white light interferometer, captures data of the biofilm in situ and non-destructively. The 3D images of biofilm surface have high resolution while maintaining a large field of view. The apparatuses and methods will be useful for fundamental studies of biofilms, biomedical and environmental screening, and many other applications in biology and the life sciences.

Method and apparatus for measuring biofilm thickness and topology

A pressure sensor and method of sensing pressure is disclosed. An fluid port is coupled to a substrate. A first microchannel within the substrate is in fluid communication with the fluid port. The first microchannel includes a first compressible fluid, a first incompressible fluid and at least one first meniscus. A second microchannel within the substrate is in fluid communication with the fluid port. The second microchannel includes a second compressible fluid, a second incompressible fluid and at least one second meniscus. A pressure of the first meniscus and/or the second meniscus is determined.

Pressure sensor using gas/liquid interface

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Richland, WA, United States of America

Jonathan D Suter