Bayer Corporation

Jonathan D Spicher

Vidyanatha A Prasad

Donald Smith

David T Erdman

Scott P Hensley

David E Cockrill

Warren A Fischer

David L Meyer

Mary F Lamar

Methods of converting methyl chloride to methyl bromide include the steps of providing a composition comprising a bromide salt and water; contacting the composition with a primary alkyl chloride; and recovering methyl bromide.

Methods for preparing primary alkyl bromides

The present invention provides a continuous process for making O,O-dimethyl phosphoroamidothioate. In accordance with this process, O,O-dimethyl phosphorochloridothioate is reacted with ammonia and sodium hydroxide; addition of the sodium hydroxide controls the pH of the reaction mixture. The formed reaction mixture contains an aqueous phase and an organic phase. The organic phase of the reaction mixture is separated from the aqueous phase; a second organic phase is solvent extracted from the aqueous phase; and the resultant O,O-dimethyl phosphoroamidothioate is isolated from the combined organic phases via vacuum solvent stripping. In an embodiment of the present invention, the reaction of O,O-dimethyl phosphorochloridothioate with ammonia and sodium hydroxide is carried out in the presence of a solvent.

Process for the synthesis of O,O-dimethyl phosphoroamidothioate

The present invention relates to a process for isolating N-(4-fluorophenyl)-N-(1-methylethyl)-2-�(5-trifluoromethyl)-1,3,4-thiadiaz ol-2-yl)oxy!acetamide from a solution of N-(4-fluorophenyl)-N-(1-methylethyl)-2-�(5-trifluoromethyl)-1,3,4-thiadiaz ol-2-yl)oxy!acetamide in an aprotic, aromatic solvent. The process includes the steps of: (a) removing the solvent from the solution to form a substantially solvent-free material; (b) melting the material from step (a) to form a molten material; and (c) isolating N-(4-fluorophenyl)-N-(1-methylethyl)-2-�(5-trifluoromethyl)-1,3,4-thiadiaz ol-2-yl)oxy!acetamide from the molten material by flaking.

Process for isolating

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Parkville, MO, United States of America

Jonathan D Spicher