Vanderbilt University

Jonathan D Macdonald

Shaun R Stauffer

Stephen W Fesik

Changho Han

Joseph R Alvarado

Taekyu Lee

Rocco D Gogliotti

Kenneth M Meyers

Alex Gregory Waterson

James M Salovich

KyuOk Jeon

William P Tansey

Jonathan J Mills

Jianhua Tian

Alexey Kuznetsov

Selena Chacon Simon

Sameer S Nikhar

Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

WDR5-MYC inhibitors

Described are imino-azacycle-benzamide compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

WDR5 inhibitors and modulators

Benzamides and picolinamides that are meta-substituted with imino-, guanidino-, or heterocycle-containing groups disrupt the WDR5-MLL1 protein-protein interaction, and have use in pharmaceutical compositions and in treating proliferative disorders and conditions in a subject, such as cancer.

WDR5-MLL1 inhibitors and modulators

Growing community of inventors

Nashville, TN, United States of America

Jonathan D Macdonald