Pulmatrix, Inc.

Jonathan Chun-Wah Man

David A Edwards

Robert William Clarke

Wesley H DeHaan

Jeffrey P Katstra

Matthew Frederick Brande

Mark J Gabrielson

Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device () contains a mouthpiece (), a filter (), a low resistance one-way valve (), a particle counter () and a computer (). Optionally, the device also contains a gas flow meter (). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual.

Method and device for decreasing contamination

Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

Formulations decreasing particle exhalation

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Bellevue, WA, United States of America

Jonathan Chun-Wah Man