Massachusetts Institute of Technology

Northwestern University

King Abdulaziz City for Science and Technology

Jonathan Christopher Barnes

Jeremiah Allen Johnson

J Fraser Stoddart

Longyan Liao

Michal Jurícek

James Fraser Stoddart

Yivan Jiang

Nicolaas Vermeulen

Hao Li

Srinivasan Sampath

Deborah June Choi Ehrlich

Ashish Neil Basuray

Edward J Dale

Albert C Fahrenbach

Angela Xiaodi Gao

Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

Drug delivery polymers and uses thereof

In some embodiments, macromolecules and related methods are provided. In some embodiments, an iterative growth process may be used to form a macromolecule comprising one or more repeat units comprising a functionalizable pendant group, with precise control over mass, length, backbone sequence, pendant group sequence, and/or stereochemistry, amongst other features. Macromolecules (e.g., non-natural macromolecules) form from the iterative growth process, described herein, may be used for a wide variety of applications, including the delivery of active agents.

Formation of macromolecules using iterative growth and related compounds

Compounds are provided for the capture of polycyclic aromatic hydrocarbons. The compound is selected from formula (I) and formula (II): The compound includes a salt formed with a suitable counter anion.

Excage: synthesis of viologen-like pyridinium-based cages for the selective capture of polycyclic aromatic hydrocarbons

Novel tetracationic cyclophanes incorporating &#x3c0;-electron poor organic compounds into their ring structures, as well as methods of making the cyclophanes, are provided. The cyclophanes are able to form electron donor-acceptor complexes with a variety of polyaromatic hydrocarbons (PAHs) ranging in size, shape, and electron density. Also provided are methods of using the cyclophanes in the sequestration of PAHs in liquid or gaseous samples, the separation of PAHs from liquid or gaseous samples, the detection of PAHs in liquid samples, and the exfoliation of graphene via pseudopolyrotaxane formation.

Tetracationic cyclophanes and their use in the sequestration of polyaromatic hydrocarbons by way of complexation

Described herein are methods of generating 4,4'-bipyridinium radical cations (BIPY), and methods for utilizing the radical-radical interactions between two or more BIPYradical cations that ensue for the creation of novel materials for applications in nanotechnology. Synthetic methodologies, crystallographic engineering techniques, methods of physical characterization, and end uses are described.

Crystalline bipyridinium radical complexes and uses thereof

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Waltham, MA, United States of America

Jonathan Christopher Barnes