Yale University

Microsoft Technology Licensing, LLC

Jonathan Chen

Rong Fan

Yao Lu

Hao Tang

Xiaosu Huang

Ziliang Lin

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

System, device and method for high-throughput multi-plexed detection

A reconnect restriction evaluator is described. After detecting that a certain number of the reconnect requests submitted by a member of an on-line social network have failed, the reconnect restriction evaluator performs additional evaluation of the history of reconnect requests stored as associated with a profile of the member and determines whether the high count of failed requests recorded against the member are offset by one or more offsetting factors. Based on the result of the additional evaluation, the reconnect restriction evaluator generates an exemption indicator and stores it as associated with the profile of the member.

Reconnect restriction evaluator

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San Jose, CA, United States of America

Jonathan Chen