Intrexon Corporation

Greenvenus, LLC

Jonathan Carson

Thomas David Reed

Amy Hobbs Atzel

Richard E Peterson

Bethany Lynn Merenick

David Bachinsky

Elena Tasheva

Joan Mazzarelli Sopczynski

Shiv Bahadur Tiwari

Charles C Reed

Sekhar Boddupalli

Arianne Tremblay

Rio Stamler

Catherine L Bair

Catherine L Keaty

Charles E Reed

Kornelie Frech

Amanda Edwards

Amy Atzel

Described is a serine recombinase that integrates large sections of foreign DNA into plant chromosomes through non-homologous recombination through attP or attB sites on the foreign DNA but without the engineering of corresponding attB or attP site on the plant chromosome. The serine recombinase-based method has several advantages over other systems, such as. Also described are related methods, composition, and plants containing exogenous DNA.

Serine recombinases mediating stable integration into plant genomes

The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate MEK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.

MEK ligands and polynucleotides encoding MEK ligands

The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.

Polynucleotides encoding therapeutic inhibitors of PAI-1

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Blacksburg, VA, United States of America

Jonathan Carson