Exelixis, Inc.

Jonathan Cagampang Heller

John William Winslow

Helen Louise Francis-Lang

R Glenn Hammonds, Jr

Darren Platt

Bindu Priya Reddy

Yuling Luo

Andrew Roy Buchman

Candace Swimmer

Casey Kopczynski

Jonathan Scott Margolis

Allen James Ebens, Jr

Greg Weddell

Christian Burks

Lucile A Gillett

Vascular Endothelial Growth Factor Receptor (dmVEGFR) nucleic acids and proteins that have been isolated from are described. The dmVEGFR nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in dmVEGPR expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential therapeutics that interact with dmVEGFR protein. They can also be used in methods for studying dmVEGFR activity and identifying other genes that modulate the function of, or interact with, the dmVEGFR gene.

Invertebrate vascular endothelial growth factor receptor

Tandem pore domain weak inward rectifying K (TWIK) channel nucleic acids and proteins that have been isolated from and Leptinotarsa are described. The TWIK channel nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects, coelomates, and pseudocoelomates, or cultured cells, resulting in TWIK channel expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with TWIK channel proteins. They can also be used in methods for studying TWIK channel activity and identifying other genes that modulate the function of, or interact with, the TWIK channel gene.

Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use

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Jonathan Cagampang Heller