Duke University

Jonathan C Poe

Thomas F Tedder

Evgueni Kountikov

Ayumi Yoshizaki

Tomomitsu Miyagaki

Yasuhito Hamaguchi

Junji Uchida

Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.

Methods of expanding and assessing B cells and using expanded B cells to treat disease

The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention further provides methods of using the monoclonal antibodies, antigen-binding fragments, and pharmaceutical compositions, for example, in methods of depleting B cells or in treating B cell disorders. Also provided are cells, nucleic acids and methods for producing the monoclonal antibodies.

CD-20 specific antibodies and methods of employing same

Growing community of inventors

Durham, NC, United States of America

Jonathan C Poe