Desmos, Inc.

Northwestern University

Jonathan C Jones

Vito Quaranta

Sigmund A Weitzman

Stephanie Stahl

Richard Tamura

A method of growing epithelial cells by contacting the cells with the extracellular matrix deposited or secreted by human MCF-10A mammary epithelial cells. The MCF-10A matrix stimulates cell attachment and hemidesmosome formation in epithelial cells contacted therewith. The invention also encompasses the isolated or purified MCF-10A matrix, compositions comprising the matrix, and shaped articles coated with the matrix.

Human epithelial cell matrix and uses therefor

A trans-epithelial appliance having a hemidesmosome formation-inducing protein composition derived from rat bladder carcinoma cells deposited thereon. This composition stimulates cell attachment and may be either the cell matrix or a soluble factor isolated from the conditioned medium. The appliance will be useful for diminishing inflammation and/or infection at the site of entry of the appliance. The appliance may also be used to stimulate gum junctional epithelium adhesion in the treatment of gingivitis and periodontitis. The composition may be used to maintain tissues ex vivo.

Cellular attachment to trans-epithelial appliances

A method for growing epithelial cells in vitro is described, The matrix secreted by 804G rat bladder carcinoma cells is able to stimulate cell attachment and hemidesmosome formation in cells grown on the matrix, Human epithelial cells grown on the 804G matrix are able to produce normal hemidesmosomes and attach to their growing substrate. Shaped articles coated with the matrix are also disclosed,

Cell matrix stimulated attachment and hemidesmosome assembly

A method for growing endocrine precursor cells in vitro, such as pancreatic islet precursors, by culturing such cells in the presence or absence of cell matrix proteins capable of promoting hemidesmosome formation, such as those produced by the rat bladder carcinoma cell line 804G.

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Chicago, IL, United States of America

Jonathan C Jones