Sicor Inc.

Jonathan Busolli

Alessandro Pontiroli

Nicola Diulgheroff

Marco Villa

Moran Pirkes

Judith Aronhime

Csilla Nemethne Racz

Francesca Scarpitta

Roberta Volonte

Zvi Harel

Volontè Roberta

Racz Csilla Nemethne

Provided are crystalline forms of N-[4-[2-(2-amino-4, 7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]ben-zoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.

Crystalline forms of pemetrexed diacid and processes for the preparation thereof

Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]ben-zoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.

Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.

Provided are processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid, in particular, pemetrexed disodium salt, directly from pemetrexed diacid or salts thereof, i.e., without isolating the obtained pemetrexed salt prior to lyophilizing it.

Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid

The invention is directed to improved processes for preparing Tiotropium bromide.

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Carisio, Italy

Jonathan Busolli