Medtronic Vascular, Inc.

Medtronic, Inc.

Jonathan Ashley Cope

Risa Tom Egerter

Gerry Oliver McCaffrey

Aran Murray

Jack Wallis

Peter Glynn

Christopher W Storment

Grainne Teresa Carroll

David J Hobbins

Conor O'Donovan

Brian Dowling

Michael Sayers

Shane Nolan

Eamon Keane

Marc A Anderson

Cian Ryan

Lana Woolley

Faraz Ul Hassan

Kieran Coughlan

Gerry Oliver Mccaffrey

Lana Wolley

Conor O'DONOVAN

Marc Anderson

Risa Egerter

David Hobbins

In some examples, a catheter includes an elongated member including at least one balloon connected to the elongated member, the at least one balloon being configured to inflate to an expanded state. In the expanded state, the at least one balloon forms at least a portion of a cavity with a wall of a vessel of the patient. The catheter including at least one electrode carried by the elongated member and having at least one surface exposed to the cavity formed by the at least one balloon. The electrode is configured to connect to an energy source that is configured to deliver, via the electrode, an electrical signal to a fluid contained in the cavity and in contact with the electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

Cavitation catheter

A catheter assembly includes a catheter comprising a flexible elongated member including a distal portion that includes a tubular body defining an inner lumen and a plurality of body apertures that extend through a sidewall of the tubular body into the inner lumen, and a plurality of primary electrodes positioned along the tubular body. The catheter assembly includes a wire defining at least one secondary electrode, the wire being configured to be slidably moved through the inner lumen of the tubular body, where the wire and the plurality of primary electrodes are configured to electrically couple to an energy source that delivers an electrical pulse to a fluid in contact with the plurality of primary electrodes and the at least one secondary electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

A delivery system for delivering a heart valve prosthesis includes a delivery catheter and a heart valve prosthesis. The delivery catheter includes an outer sheath, an inner shaft, a distal nosecone, and a deflecting segment. The inner shaft is slidably disposed within the outer sheath. A distal end of the inner shaft is coupled to a proximal end of the deflecting segment, and a distal end of the deflecting segment is coupled to the distal nosecone. The deflecting segment includes a delivery state with the deflecting segment and the distal nosecone having a combined first longitudinal length. The deflecting segment further includes a deflected state with the deflecting segment having a second longitudinal length that is less than the first longitudinal length. The heart valve prosthesis includes a radially collapsed configuration and a radially expanded configuration. The deflecting segment is shape-set to the deflected state.

Transseptal delivery systems having a deflecting segment and methods of use

Methods and apparatus are disclosed for customizing an elution rate of a stent. The stent includes a hollow strut that forms the stent, the hollow strut defining a lumenal space, a drug formulation disposed within the lumenal space of the hollow strut, and at least one side port for eluting the drug formulation in vivo. When the stent is in the radially expanded configuration the hollow strut is deformable from a first configuration that has a first elution rate for the drug formulation to a second configuration that has a second elution rate for the drug formulation. The second elution rate is faster than the first elution rate. The hollow strut deforms from the first configuration to the second configuration upon application of an applied pressure above a predetermined threshold.

Drug-eluting stent formed from a deformable hollow strut for a customizable elution rate

Methods and apparatus are disclosed for customizing an elution profile of a stent after manufacture of the stent has been completed. The stent includes a plurality of side ports for eluting a drug formulation within a lumenal space of a hollow strut that forms the stent. An effective diameter of at least one side port of the plurality of side ports of the stent is modified in order to customize an elution profile of the stent. In an embodiment hereof, the plurality of side ports are completely blocked or plugged with a filler material during the manufacture of the stent and at least a portion of the filler material is removed to increase an effective diameter of at least one side port of the plurality of side ports of the stent in order to customize an elution profile of the stent. In another embodiment hereof, the plurality of side ports are open following the manufacture of the stent and at least one side port of the plurality of side ports of the stent is at least partially filled with a filler material to decrease the effective diameter of the at least one side port in order to customize an elution profile of the stent. In another embodiment hereof, the stent is soaked within a liquid to remove at least a portion of the drug formulation from the lumenal space of the hollow strut to thereby customize an elution profile of the stent.

Customizing the elution profile of a stent

Growing community of inventors

Santa Rosa, CA, United States of America

Jonathan Ashley Cope