Wisconsin Alumni Research Foundation

Affinergy Inc.

Jonathan Allen Hodges

Ronald Thaddeus Raines

Matthew D Shoulders

Paul Theodore Hamilton

Shrikumar Ambujakshan Nair

Hanne Gron

Yuchen Chen

Martyn Kerry Darby

Isaac Gilliam Sanford

Ganesan Sathya

Michelle Steffen Jansen

Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly), where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.

Collagen mimics

Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly),where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.

Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

Methods and compositions for soft tissue repair

A novel collagen mimic comprising a tripeptide unit having the formula (flpYaaGly), where flp is 4(S)-fluoro-L-proline, is disclosed. The collagen mimic has increased stability relative to the collagen-related triple helices (ProYaaGly), (hypYaaGly), and (HypYaaGly).

Growing community of inventors

Durham, NC, United States of America

Jonathan Allen Hodges