Ge Healthcare Bio-sciences Corp.

Global Life Sciences Solutions USA LLC

Cytiva Sweden Ab

Jonathan A Kenney

Colin R Tuohey

Richard Lee Damren

Thomas John Erdenberger

Parrish M Galliher

Michael Edward Fisher

Ralph Stankowski

Patrik Berndt Akerstrom

Joseph D Crowell

Klaus Gebauer

Mats Olsson

Kenneth P Clapp

Anindya Kanti De

Nirmal Kumar Thanikachalam

Anindya Sengupta

Nagaraj Raghavendra Rao

David Lawrence Brazell

Wei Jin

Roberto Miguel Cabral

Sampath Telikcherla Kandala

Ethan Michael Barrieau

Eric Tenander

Michael Fisher

Richard L Damren

Thomas Erdenberger

Sampath Telikherla Kandala

A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

Housing for holding a flexible bioprocess bag and method for assembling the bag in the housing

A connection clamping device () arranged for securing a flexible tube () to a barbed end () of a tube connector (), whereby the barbed end () comprises a barb () and the tube connector during connection is arranged to protrude into an end of the flexible tube (), characterized in that said connection clamping device comprises two sections () which, during connection when the tube connector protrudes into an end of the flexible tube, are arranged to be connected and locked to each other by a locking mechanism () around the tube connector () and the flexible tube (), such that the flexible tube () is compressed against the tube connector () by a rib () provided on the inner circumference of the connection clamping device.

Connection clamping device

A bioprocess mixer (), which comprises: &#x2014;a support vessel () with at least one side wall () and a bottom wall (), where the walls define a support vessel inner volume (), and at least a first () and a second () magnetic impeller drive unit; and &#x2014;a flexible bag () adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (), a bag bottom wall () and a bag top wall () defining a bag inner volume (), and at least a first () and a second () magnetic impeller rotatably attached to a bag wall in the bag inner volume.

Bioprocess mixer

Housing for holding a flexible bioprocess bag

A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.

Probe assembly

Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.

Disposable valve and flexible containers for pressurized bioreactors

A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.

Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are 'receiver-less' retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator.

Single-use mixing and bioreactor systems

Mixer bag support vessel

Growing community of inventors

Lakeville, MA, United States of America

Jonathan A Kenney