Abbvie Inc.

Abbvie Biotherapeutics Inc.

Jonathan A Hickson

Jijie Gu

Susan Elizabeth Morgan-Lappe

Yingchun Li

Chung-Ming Hsieh

Kurt C Gish

Ravi Chari

Lorenzo Benatuil

Yuliya Kutskova

Supriya Gupta

Camellia Zamiri

Dominic J Ambrosi

Erwin R Boghaert

Maria Harris

Louie Naumovski

Susan E Lappe

James W Purcell

Zhihong Liu

Deanna L Haasch

Xianhua Cao

The present disclosure provides antibodies, antibody binding fragments, and antibody drug conjugates that bind human LRRC15, their methods of making, and their uses to treat patients having cancer.

Anti-huLRRC15 antibody drug conjugates and methods for their use

Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.

Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof

Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.

Therapeutic DLL4 binding proteins

Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.

Growing community of inventors

Lake Villa, IL, United States of America

Jonathan A Hickson