Amplyx Pharmaceuticals, Inc.

Duke University

University of Utah Research Foundation

Arena Pharmaceuticals, Inc.

Basilea Pharmaceutica International Ag, Allschwil

Jonathan A Covel

Peter J Webb

Robert Remme Webb, Ii

Mitchell Mutz

Michael Trzoss

Andrei William Konradi

Yifeng Xiong

Thuy-Anh Tran

Graeme Semple

Albert S Ren

Anh P Truong

Dennie S Welch

Karen Joy Shaw

Wei Zheng

Carina Cristina Sanchez

Wei Li

Yam Poudel

Michael Grey

Zheng Wei

Gary E Keck

Matthew B Kraft

Andrei W Konradi

Described herein are heterocycle substituted pyridine derivative antifungal agents and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of fungal diseases and infections.

Heterocycle substituted pyridine derivative antifungal agents

Described herein are pyridine derivatives substituted by heterocycle and amino groups and pharmaceutical compositions comprising said compounds. The disclosed compounds are antifungal agents. The subject compounds and compositions are useful for the treatment of fungal diseases and infections.

Pyridine derivatives substituted by heterocyclic ring and amino group

The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.

Antifungal compounds

The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, that modulate the activity of the histamine H3 receptor (Ia). Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders. 

Biphenyl-ethyl-pyrrolidine derivatives as histamine H3 receptor modulators for the treatment of cognitive disorders

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.

Bryostatin analogues and methods of making and using thereof

Growing community of inventors

San Diego, CA, United States of America

Jonathan A Covel